Although ESCs can tolerate DNA hypomethylation without impairment of cell proliferation (Tsumura et al., 2006), hypomethylation nonetheless impairs the capability of ESCs to achieve, and maintain a differentiated state (Feldman et al., 2006; Jackson et al., 2004; Sinkkonen et al., 2008).
Biliary obstruction itself disadvantages the immune system and impairs its capability to fight infection, by impairing the function of certain immune system cells (neutrophil granulocytes) and modifying the levels of immune hormones (cytokines).
Partial (in detached retinas) or total depletion of Dp71 in Müller cells (in Dp71-null mice) impairs the capability of volume regulation of Müller cells under osmotic stress.
Further, in a single-case study, Goel and Grafman [81] demonstrated that a right prefrontal cortex lesion severely impairs the capability to generate solutions for ill-constrained problems and also the capability to restructure or break the mental fixedness.
This depletion impairs individuals' capability of coping with further stress, thus resulting in a vicious circle.
By binding to NCAM, it increases the hydrodynamic area of the cells extern proximity and impairs the capability of NCAM to maintain the cell adhesion structures between other cells and the ECM [ 3, 6].
In those cases, the population faces two important difficulties: first, it has to go again through the adapting transient, where the target structure has not yet been found; second, the reduction in the population size impairs the capability of the ensemble to generate beneficial variants.
(B) Filtration treatment did not impair the capability of the AMV reverse transcriptase to perform their function in different concentrations.
Consistently, the function test showed that filtration treatment did not impair the capability of the AMV reverse transcriptase to perform their function in different concentration (Fig. 2B).
Open image in new window Figure 2 Filtration decreases the miRNA contents without impairing the capability of the AMV reverse transcriptase.
We stopped the procedure for safety reasons due to the particular position of the myoma as the intramural part of the myoma was compressing the serosal surface, impairing our capability to assess the safety margin of resection.
