In conclusion, undernutrition impaired the viability of sheep embryos in the RS, particularly among ewes that were given melatonin supplements subcutaneously, but melatonin appeared to improve embryo quality in the AS, which suggests that the mechanisms involved in the interactive effects of melatonin and nutrition on embryo development are influenced by season.
Third, the complement system, which is activated during sepsis, may impair the viability of erythrocytes [ 22].
The results indicated that SOX11 knockdown significantly impaired the viability and proliferation of both cell types.
The silencing of five of these genes selectively impaired the viability of HuH6 cells with high β-catenin signaling: HGS, STRADA, FES, BRAF and PKMYT1.
Out of a pool of 305 shRNAs, we identified 28 candidate shRNAs to fully or partially impair the viability of the breast carcinoma cell line MDA-MB-231.
Uncontrolled expression of a single ABC transporter can impair the viability of nonreplicating mycobacteria and therefore may be used as a strategy to kill them.
GDPs impair the viability and functional integrity of mesothelial cells upon extended exposure [ 10], and stimulate VEGF and TGF-β release by mesothelial cells [ 11, 12].
Consequently, we have performed high-throughput screens for protein kinases, which are upregulated in pancreatic cancer and, which, when silenced, would impair the viability of pancreatic cancer cells.
A buffered solution of 4 m LiCl with aw of 0.73, on the other hand, was conducive for the formation of spheres and did not immediately impair the viability of haloarchaea.
We found significant downregulation of ABCA1 levels in the prefrontal cortex of Goto-Kakizaki rats (Additional File 2); hence it seems logical to assume that elevated cytosolic cholesterol levels might impair the viability of neurons via affecting membrane fluidity.
