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Together, these results demonstrate that the loss of spastin microtubule-severing activity significantly impairs the number of dynamic microtubule plus ends within cortical axon shafts, without affecting the polymerization rate of the remaining plus ends.
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Diabetes is known to impair the number and function of endothelial progenitor cells in the circulation, causing structural and functional alterations in the micro- and macro-vasculature.
In these cases, autophagic flux was impaired, the number of autophagic vacuoles increased and autophagic substrates accumulated in the affected tissues [ 49, 89].
Even though nodule initiation appears not to be impaired, the number of invaded primordia was markedly reduced in MtN5-silenced roots.
The morphology of neuron and synaptic structure was impaired; the number of TUNEL-positive cells and the expression of CHOP in hippocampus of diabetic rats and high glucose medium cultured neurons were markedly altered (P < 0.05).
Besides, CRP could stimulate leucocyte-endothelium interactions [ 38], decrease endothelial nitric oxide [ 39], and impair the number and function of endothelial progenitor cells [ 40], thereby promoting endothelial dysfunction, which is another important mediator in the development of diabetic microvascular complications [ 15].
At the typical ratio of aerosol to sheath air flow 1 10, a leak in the sheath air flow of 1% results in a 10% error in the aerosol flow which directly impairs the particle number concentration.
These data suggest that, when using DC as the APC for optimal priming of naive T cells, irradiation impairs both the number and cytotoxicity of the effector cells generated.
These data suggest that decreasing the stringency of the search (increasing the intervening arbitrary residue number) impairs the fidelity of the search.
Moreover, positioning and maturation of Paneth and goblet cells is severely impaired and the number of goblet cells is reduced.
In fact, in the authors' experience, in the case of patients, the single gesture acquisition time can increase but it never goes beyond 1 minute; moreover, in the case of severe impaired patients, the number of repetitions may be reduced and each gesture (RM or HtMM) may be evaluated only once; the downtime also can increase as the patient may have to rest between two trials.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com