Hoarding disorder is characterized by difficulty parting with possessions and by clutter that impairs the functionality of living spaces.
If a lesion impairs the functionality of neuronal circuits contributing to language, such modulation of neuronal functionality can have a beneficial effect on language performance (Albert, Bachman, Morgan, & Helm-Estabrooks, 1988; Berthier, 2005; Shisler, Baylis, & Frank, 2000).
We also investigated if the reactive oxygen species-activated ICl,SWELL impairs the functionality of angiotensin-(1 7)- Mas receptors in diabetic rat carotid, by obtaining angiotensin II-evoked relaxant curves in the presence of DCPIB (10 μmol/L, 10 min).
Thus, our previous findings [ 8] allow us to hypothesize that endothelial AT1-activated NAD(P H oxidase-driven generation of reactive oxygen species during type I-diabetes impairs the functionality of ACE2-angiotensin(1 7)- Mas axis in rat carotid by inhibiting both the hydrolysis of angiotensin II into angiotensin-(1 7) and the nitrergic signaling pathway underlying Mas receptors activation.
In this study, we report that mir-660 is downregulated in tissue and plasma samples of lung cancer patients and demonstrate that mir-660 replacement impairs the functionality of p53 wild-type (wt) lung cancer cells and inhibits in vitro and in vivo tumor growth.
This is the first study that shows that the endothelial AT1-activated NAD(P H oxidase-driven generation of O2− and H2O2 in carotid arteries from type I-diabetic rats impairs the functionality of the local vasoprotective ACE2-angiotensin(1 7)- Mas axis, which in turn impairs carotid blood flow.
Their hydrophilicity/hydrophobicity is balanced, allowing them to perform physiological functions by interacting with some of these anionic structures, without impairing the functionality of others.
An uncooperative choice of transmission power by each single vehicle, however, leads to "uncontrolled" load on the communication channel, thus, impairing the functionality of the communication system.
Although the relBE2Spn operon exhibited various degrees of polymorphisms in the different isolates, none of the changes impaired the functionality of the relBE2Spn locus.
Instability is crucial for impairing the functionality of missense mutant pVHLs.
