Sentence examples for impairs the functional from inspiring English sources

Apart from the decline in CD4+ T cell numbers, HIV-1 infection also impairs the functional and phenotypic heterogeneity of HIV-1 specific CD4+ T cells.

The potential drawback of this schedule is that pretreatment with the VDA impairs the functional properties of the tumour vasculature, hence possibly affecting the distribution of PTX within the tumour.

Hence, increasing dopamine levels impairs the functional discrimination of memory cues in the SN/VTA, hippocampus, and parahippocampal cortex, while at the same time causing increased responsiveness in otherwise unresponsive regions of the hippocampus and parahippocampal cortex.

Previous reports have shown that accumulation of protein aggregates of model disease proteins of human neurological disorders impairs the functional capacity of the UPS [ 24- 27] but to what extent aggregation of indigenous proteins is causing a decline in UPS performance during aging has not been shown.

It appears that this legislative form of restraint does not impair the functional improvement of this population.

Meanwhile, the possibly enhanced production of the reactive oxygen species could be renotoxic consequently impairing the functional capacity of the kidney.

Understanding these is important as patellar tendinopathy may contribute to activity-related knee pain which may impair the functional activities of the knee [ 14].

On the basis of these observations, we conclude that the immunotoxic effects of PRN exposure on CTLs are delayed in their appearance and directly impair the functional activity of these effectors of cell-mediated immunity.

Although the mechanisms by which unmodified CdSe QDs elevated cytoplasmic calcium concentrations and impaired the functional properties of sodium channels in cultured hippocampal neurons remain a matter of conjecture, our results provide new insights into QD toxicology and present the potential risks of QD application, especially in the CNS, for scientific and clinical usage.

Loss of spermatogonial function impairs the generation of functional gametes thereby leading to infertility [ 8].

However, mild to moderate anemia occurs or persists in some individuals on long-term therapy and gradually impairs the individual's functional status [ 2, 8, 21].