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Although ESCs can tolerate DNA hypomethylation without impairment of cell proliferation (Tsumura et al., 2006), hypomethylation nonetheless impairs the capability of ESCs to achieve, and maintain a differentiated state (Feldman et al., 2006; Jackson et al., 2004; Sinkkonen et al., 2008).
Partial (in detached retinas) or total depletion of Dp71 in Müller cells (in Dp71-null mice) impairs the capability of volume regulation of Müller cells under osmotic stress.
Further, in a single-case study, Goel and Grafman [81] demonstrated that a right prefrontal cortex lesion severely impairs the capability to generate solutions for ill-constrained problems and also the capability to restructure or break the mental fixedness.
By binding to NCAM, it increases the hydrodynamic area of the cells extern proximity and impairs the capability of NCAM to maintain the cell adhesion structures between other cells and the ECM [ 3, 6].
In those cases, the population faces two important difficulties: first, it has to go again through the adapting transient, where the target structure has not yet been found; second, the reduction in the population size impairs the capability of the ensemble to generate beneficial variants.
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(B) Filtration treatment did not impair the capability of the AMV reverse transcriptase to perform their function in different concentrations.
Consistently, the function test showed that filtration treatment did not impair the capability of the AMV reverse transcriptase to perform their function in different concentration (Fig. 2B).
Open image in new window Figure 2 Filtration decreases the miRNA contents without impairing the capability of the AMV reverse transcriptase.
The still continuing problem of Iron Mountain Mine runoff has once been described as: The construction of Shasta Dam and its afterbay (regulating downstream dam), Keswick Dam, in 1943 and 1950, respectively, severely impaired the capability of the Sacramento River to flush away pollutants from the mine.
These data support the idea that the probable phosphorylation-defective mutations in the 3 m1 or M3 motifs significantly impaired the capability of PIN1 and PIN7 to target to the PM and thus resulted in suppression of PIN-mediated root hair inhibition.
Since AP-1 mediates the action of LPS, TCDD would thus impair the capability of LPS to drive the switching of the transcriptional gene circuit that underlies B-to-plasma cell differentiation, thereby suppressing the formation of antibody-secreting plasma cells [ 6].
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