Once the threshold temperature is reached, the barrier function could be impaired rapidly and with short exposure times.
Their findings indicated that CYP2C19 is impaired more rapidly than other cytochrome P450 species, such as CYP1A2 or CYP2D6, during the development of hepatic functional impairment.
Inflammation rapidly impairs mood and cognition and, when severe, can appear indistinguishable from major depression.
Though clinically effective, IFN-α rapidly impairs mood, motivation and cognition, effects that can appear indistinguishable from major depression and provide powerful empirical support for the inflammation theory of depression.
Their results suggest that postprandial hyperglycemia rapidly impairs endothelial function through an increase in hyperglycemia-induced oxidative stress.
Consequently, the drug can deeply penetrate into the plasma membrane, and rapidly impair selected enzymic activities leading to cell death.
In contrast, it has also been reported that Aβ rapidly impair mitochondrial transport without affecting mitochondrial function or the cytoskeleton in hippocampal neurons [42].
Stoet & Snyder [13] reported that dyslexics may have impaired capacity to rapidly shift their visual attention in a task-switching paradigm; yet, the deficit, according to these authors, would be more at the peripheral neural pathways such as the magnocellular layers in the lateral geniculate nucleus rather than at a central cognitive level.
In addition, metabolic activity of the 5637 cells was rapidly impaired, and cell cycle arrest was induced at 1-3% cis-UCA.
We can thus speculate that the ability of the cells to detect the stiff matrix they are normally seeded on has become rapidly impaired.
