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At present the reasons why proinflammatory environment impairs proliferation and survival more potently but leaves neuronal maturation more or less intact are not clear.
Inhibition of STAT3 activity impairs proliferation and induces apoptosis [ 7].
Thus, lack of GDF15 impairs proliferation and migration in the developing HP.
Inhibition of LSD1 impairs proliferation and invasiveness, and induces apoptosis of colon cancer cells in vitro.
Other in vivo studies have provided evidence that BPA impairs proliferation in the uterus.
HIF1A expression is critical for cancer cell growth, and its knock-down impairs proliferation (Semenza, 2000; Seagroves et al, 2001).
Similar(36)
However, U2OS/MTX300 cells exhibited higher proliferating ability in SFM, whereas U2OS cells showed impaired proliferation in SFM.
T lymphocytes lacking Atg5, Atg7, Atg3 or Beclin-1 all showed impaired proliferation and enhanced cell death.
Hypocellularity and hypoplasia start at early developmental stages and likely depend upon impaired proliferation of neuronal precursors, resulting in reduction of numbers of neurons and synaptic contacts.
Cdr2 knockdown cells also exhibit impaired proliferation, while cdr2 overexpression drives proliferation in tumors.
p56Lck deficiency has been found previously to impair proliferation of T cells in lymphopenic recipients [31].
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