In our simulation, where every predictor takes 1 df, this AIC-based simplification is equivalent to always removing the least significant term if removal does not impair model fit.
The flexibility of this loop impaired modeling of the Ala257-His258-Arg259 segmenthen ternarynary complex.
Another important consideration is that some of these variables may be endogenous and thus might require special treatment in order to not impair the model.
Hypothyroidism disrupts growth plate chondrocyte differentiation leading to delayed endochondral ossification and linear growth, impairs bone modeling, and uncouples the processes of osteoclastic bone resorption and osteoblastic bone formation (43).
Previous studies showed that expression of REST might be impaired in models of polyglutamine disorders [32], [33].
The function of the ubiquitin-proteasome system (UPS) is impaired in models of neurodegeneration, and overexpression of chaperone proteins, such as those in the HSP70 family, leads to beneficial effects in many models of proteinopathies.
The delayed ossification persists into adulthood and is accompanied by impaired bone modeling and remodeling, resulting in short stature, increased bone mass, and gross morphologic abnormalities of the bones and joints, but normal bone strength.
Introduce the child to various blind and visually impaired role models.
A modest sample size at level 2 (77 classes) impairs the measurement model fit of teachers' work enjoyment, but using manifest variables to avoid these constraints would have simply ignored measurement errors.
One might argue that the simplicity of the model impairs its abilitiy to uncover unanticipated results.
