Very recently, tef1 knock-down has been reported to globally impair light induced gene expression compared with uninjected controls in 9 hours post fertilization zebrafish embryos that were raised in constant light [73].
On the other hand, glutamate receptor antagonists (NBQX, CPP) did not impair light-induced c-Fos expression, indicating that synaptic activity was not required to induce c-Fos.
As the genome scale analysis suggests that cli186 is specifically impaired in the regulation of genes affected by L/C interactions, it was of interest to compare gene regulation in cli186 to other Arabidopsis mutants impaired in light sensing/signaling.
Even if hugely-increased densities of ChR2-YFP-NavII-III could be precisely localised to the AIS, then, they might out-compete native VGSCs to such an extent that action potential initiation is impaired and light-evoked spiking remains impossible.
Results from three experiments involving color and reading show that red light impairs reading performance under normal luminance contrast conditions.
Therefore, there appears to be a strong metabolic advantage to daily vertical migration, even to depths where shark foraging efficiency is impaired by low light.
On the other hand, among environmental factors that may impair photoreceptor survival, light toxicity has been intensely investigated.
Bedrosian, T. A. et al. Nocturnal light exposure impairs affective responses in a wavelength-dependent manner.
The patient, who remains anonymous, suffers from a disease called Leber congenital amaurosis, in which an abnormal protein in sufferers' photoreceptors severely impairs their sensitivity to light.
LeGates TA, Altimus CM, Wang H, Lee HK, Yang S, Zhao H, Kirkwood A, Weber ET, Hattar S. Aberrant light directly impairs mood and learning through melanopsin-expressing neurons.
