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Specifically, loss of function of limb muscles impairs functional independence and loss of diaphragm function is implicated in respiratory failure (Murphy et al., 2011).
Because loss of muscle strength impairs functional independence and loss of diaphragm function might be implicated in respiratory failure, it is important that studies evaluating the therapeutic potential of an intervention for cancer cachexia include assessments of limb and diaphragm muscle function.
Previous studies showed that homocysteine (Hcy) reduces endothelial progenitor cells (EPCs) numbers and impairs functional activity.
We previously demonstrated that transient hyperglycemia during acute SCI is a detrimental factor that impairs functional improvement in mice and human patients after acute SCI[2].
It also could imply that some persistent fluid impairs functional outcomes.
Furthermore, blocking ADAM17 impairs functional recovery, increasing lesion size, astrogliosis, and microglial apoptosis after SCI.
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ICU-AW is associated with short-term and long-term physical impairments and impaired functional status [ 1].
It is possible, therefore, that NRP1 antagonists and siRNAs could indirectly affect tumour cell function by impairing functional signalling mediated via other receptors such as c-Met.
Then, postoperative radiotherapy (RT) improves survival without impairing functional status or neurocognitive functions, compared with best supportive care only following resection.
Patients recovering from critical illness may show persisting organ dysfunction that could impair functional status (physical, social, emotional function) with an associated reduced health-related quality of life (HRQOL).
Patients who survive sepsis often have severely compromised organ function that may result in persistent physical and psychological symptoms (dyspnoea, fatigue and depression), impaired functional status (physical, social and emotional function) and reduced health-related quality of life (HRQoL) [ 6].
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