These are potentially examples of clients that have, at least partially, lost their dependency on Hsp90 and evade Hsp90 inhibition effects, which could impair effectiveness of cancer treatment.
However, response to analgesics and triptans can also change over time and depending on the frequency of usage (medication overuse headache impairing effectiveness of abortive medication).
Diabetes mellitus is recognized as a group of heterogeneous disorders, with common elements of hyperglycemia and glucose intolerance due to insulin deficiency, impaired effectiveness of insulin action, or both.
Diabetes mellitus is a heterogeneous disorder that is manifested in the form of hyperglycemia and glucose intolerance due to relative insulin deficiency, impaired effectiveness of insulin action, or both.
It can make us defensive, angry, and self-conscious, which subsequently impairs our effectiveness.
This matrix of proteins and polysaccharides shield organisms from the environment15, and impairs the effectiveness of both antibiotics and the immune response16, 17.
In fact smokers are four times more likely to develop AMD and smoking even impairs the effectiveness of AMD treatment.
Cisplatin is the treatment backbone in a variety of cancers including gastric cancer, but intrinsic and acquired resistance impairs its effectiveness to a high degree.
It is, therefore, pivotal to know the experience and opinion of MDT coordinators on these matters so that we can understand what improves, or impairs the effectiveness of an MDT.
Rejecting the commission's work on this issue would fatally impair its effectiveness, and without an effective Advisory Commission, the historic district itself is a dead letter.
