Sentence examples for impairs adipogenesis from inspiring English sources

The activation of SIRT1 impairs adipogenesis and enhances MSC osteogenesis.

In addition, transcriptional modulator TAZ interacts with Runx2 to promote osteogenesis, whereas binding of TAZ to PPAR γ impairs adipogenesis.

55, 59 Consistent with these observations, in vitro assays have shown that a paternally inherited Gsα-inactivating mutation impairs adipogenesis and enhances osteogenesis in MSCs.

Knockdown of Dact1 impairs adipogenesis and constitutive overexpression of Dact1 promotes adipogenesis through inhibition/activation of the Wnt/β-catenin signaling [ 8].

DMA3+ did not affect DMI-induced reduction of CHOP10 protein expression during the early stage of adipogenesis, suggesting DMA3+ impairs adipogenesis by a different mechanism.

In the present study, we found that low-level iAs and its trivalent monomethylated metabolite trigger UPR and up-regulate CHOP10, which suppresses C/EBPβ transcriptional activity and thus impairs adipogenesis.

Since impaired adipogenesis and ectopic lipid accumulation are closely related to insulin resistance [22], [23], a deterioration of adipose tissue function with aging is likely to contribute to impaired glucose homeostasis.

Thus, redundant, stress responsive, inherent processes impair adipogenesis with aging.

Cells isolated from seipin knockout mouse models also exhibit impaired adipogenesis.

More recently, miR-130 overexpression was also found to impair adipogenesis and to repress PPARγ.

Small-interference RNA-mediated knock- down of SCD1 in adipocytes impaired adipogenesis and decreased PPARγ protein levels [ 26, 27].