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Impairments of learning and memory are common neuropsychological sequelae of chronic alcohol abuse.
In this article, we argue that these properties of eyeblink conditioning make it an excellent model system for studying early impairments of learning and memory in developmental neurotoxicology.
Dramatic decline in neurogenesis has been proven to contribute to the impairments of learning and memory in AD models [ 26, 27].
KI mice also display behavioral phenotypes similar to those seen in human FXPM individuals, such as motor deficits, anxiety, and impairments of learning and memory (Van Dam et al., 2005; Hunsaker et al., 2009, 2011, 2012; Qin et al., 2011; Diep et al., 2012).
Conversely NBM lesions in animals have been shown to block this electrocortical activation (Buzsaki et al., 1988; Fuller et al., 2011), and cause impairments of learning and memory (Bartus et al., 1985; Mandel et al., 1989; Butt and Hodge, 1995; Leanza et al., 1996), as well as impairments in orienting of attention (Voytko et al., 1994; Voytko, 1996).
Children with cerebral palsy were studied because they often have impairments of learning, hearing, vision, communication and epilepsy in addition to motor impairment and so are more representative of disabled children than a group with for example just epilepsy or movement difficulties.
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This was recognized by DeStefano and LeFevre [DeStefano, D., & LeFevre, J. -A., (2007). Cognitive load in hypertext reading: A review. Computers in Human Behavior, 23(3), 1616 1641.] who predicted an increase of cognitive load and impairment of learning for hypertexts with a higher number of links per page.
Moreover, acute crowding of solitarious locusts to gregarize them does not inhibit appetitive associative learning, demonstrating that the impairment of aversive associative learning is specific rather than a general impairment of learning.
In general, the reduction of potassium currents has been linked to changes in the neuronal action potential structure, to a reduction in AHP amplitude, and possibly to impairment of learning ability (Disterhoft et al., 1996; Giese et al., 1998).
The deposition of β-amyloid protein in the brain is related to the impairment of learning and cholinergic neuronal degeneration and the β-amyloid protein-treated rats could be used as animal model for AD [ 14].
To our knowledge, only Troyer et al. (2008) [ 14] examined this issue, but they did not find any difference in the impairment of learning rate between item and associative memory.
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