Exact(1)
Since short- and long-term memories are intact in the cdc42 depleted mice but in contrast remote memory is impaired it would be important to examine the effects of the absence of cdc42 on synaptic and structural plasticity in cortex in addition to the hippocampus since the behavioral impairments indicate also on cortical functional impairments.
Similar(59)
However, only five children had more than two impairments, indicating that the deficits were selective, not pervasive.
Furthermore, the diagnosis should not be applied to justify the use of stimulant medication to enhance performance in the absence of a wider range of significant impairments indicating a mental health disorder.
The results support the view that high rates of hippocampal loss in mild cognitive impairment indicate Alzheimer's disease pathology.
The MOH patients also presented lower MoCA score, and this cognitive impairment indicated that the decreased FCD of right parahippocampal gyrus was related with the cognitive ability [27].
In other studies of mitochondrial motility, inhibitory effects on mitochondrial movement have generally been consistent with mitochondrial impairment, indicated by a loss of membrane potential and drastic changes in mitochondrial morphology [7], [8], [20], [21].
Eighteen percent of participants had cognitive impairment, indicated by a MMSE less than 25/30.
Exclusion criteria were: (I) focal neurological abnormalities on physical examination; (II) generalized or extratemporal EEG spikes; (III) marked cognitive impairment indicating dysfunction beyond the temporal regions.
In the domain of chronic pathology only a predisposing cognitive impairment, indicating an established diagnosis of dementia, was a risk factor (Table 4).
Exclusion criteria were: (I) focal neurological abnormalities on physical examination; (II) generalized or extra-temporal EEG spikes; (III) marked cognitive impairment indicating dysfunction beyond the temporal regions.
Most of the records had fairly low scores for neurological function impairment, indicating that the severity of the patient's condition was minor to medium (see Table 5).
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