In addition, experiments using T cell co-cultures demonstrated that the vhs protein impaired the development of Th1 immunity as shown by the impairment in the expression of a number of Th1-related genes.
Another possibility is impairment in the expression of miR-146a, which is known to target STAT1 [ 46].
If the classical 'purely molecular' view of gene regulation holds, we expect that macrophages coming from MyD88- and TRIF- knocked out mice, when challenged with LPS stimulation, to have a severe impairment in the expression of genes linked to the immune response, while the other should remain substantially unchanged.
Ex vivo APL blasts electroporation with EZN-2968 led to significant impairment in the expression of HIF-1α and HIF-target genes (Fig 4C) and inhibited basal and SDF-1-directed cell migration, CFU-L formation and leukemia involvement in peripheral blood (Fig 4D-F), leading to increased mice survival (Fig 4G).
Augmentative and alternative communication is used by individuals to compensate for severe speech-language impairments in the expression or comprehension of spoken or written language.
While no data on erm(A) functionality in Enterobacteriaceae has been found, previous studies have described an impairment in the expression levels of erm(C 36, which, if combined with a limited gene copy number, might result in a marginal influence on azithromycin MIC levels such as those detected in present study.
Core to the development of the test battery was the idea that an underlying cognitive deficit was implicated in the expression of language/literacy impairments.
The significant reduction in the expression of TNF by TLR2-deficient macrophages infected in vitro and the significant reduction of TNF expression in the lungs of TLR2−/− mice infected with LVS is striking and suggests that the increased susceptibility of TLR2-deficient mice to infection can perhaps be accounted for solely by the impairment of TNF expression in vivo early in the infection.
Obese individuals feature elevated plasma leptin levels, indicating leptin resistance, which may be caused by impairment in the leptin binding protein that takes leptin to the brain, impairment in the expression and/or signaling of the brain leptin receptor, and impairment in the leptin synthesis/secretion by adipocytes.
In parallel, Capps, Yirmiya, and Sigman[ 20] observed a greater impairment in recognizing and labelling the expression of those emotions that have an external locus of control and, simultaneously, that require a wide knowledge of the social scripts and of their social consequences.
