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The scale also facilitates a fractional interpretation of cognitive impairment in study patients, relative to severely impaired patients, who have a cognitive impairment score of 100 points.
The level of functional impairment in relation to work or school, social life and home life and family responsibilities was recorded on the SDS [ 17] using self-reported 10-point visual analogue scales and summated into a global functional impairment score (maximum 30 = highly impaired).
Electrocardiogram and neurologic impairment score did not show significant change at 12 months.
Neurologic impairment score and electromyogram were determined at baseline and 12 months.
Impairment of daily life was measured with the impairment score.
(Maximum impairment score = 10) (Pfeiffer 1975) 0.8 ± 1.8 Barthel Activities of Daily Living (ADL) score.
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Level of functional impairment was rated by the therapists on the Impairment-Score for Children and Adolescents (IS-CA; [ 13]).
Note: a) cut-off T > 45 above average; b) T-scores, cut-off > 60 clinical/dysfunctional range; c) cut-off > 7 clinical range; YSR = Youth Self Report, CBCL = Child Behavior Checklist, IS-CA = Impairment-Score for Children and Adolescents; self-report n = 73, parent report n = 103.
Asymptomatic status was determined if gene carriers scored '0' in all three clinical polyneuropathy scores (Neuropathy Impairment Score lower limbs, Neuropathy Deficit Score, Neuropathy Symptom Score).
All patients received detailed neurological and electrophysiological examinations and were scored using the Neuropathy Impairment Score Lower Limbs, Neuropathy Deficit and Neuropathy Symptom Score.
Absence of symptomatic polyneuropathy in these seven subjects was confirmed by detailed clinical neurological examinations and a score of 0 in Neuropathy Symptom Score, Neuropathy Deficit Score and Neuropathy Impairment Score lower limbs (Table 1).
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