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This impairment reflected the deterioration of sympathetic nerve function (10).
This coincided with metabolic impairment reflected by an increase in extracellular cerebral lactate and decrease in extracellular glucose measured by microdialysis [ 58].
It is possible that such patients had greater levels of impairment (reflected in their inability to give informed consent) and would have been more dependent on services.
Children febrile ≥ 7 days (equivalent to minimum time to FU) constituted the "Prolonged Fever" status group, while "Any Functional Impairment" reflected subjects reporting ≥ 7 days in one or more domains of functional impairment (activity, oral intake, sleep, behavior).
However, particularly for vision, cognition and mood impairment, many more participants were considered by the clinician to have the impairment, reflected in the large discrepancy in prevalence, the low sensitivity of the COPE assessment, and the low levels of agreement.
Measuring pathologic L/P values at ptiO2 levels exceeding the ischemic threshold of 10 mmHg (median: 30 mmHg, Table 1) [ 35] suggests that mitochondrial dysfunction is the underlying cause for the observed signs of metabolic impairment reflected by elevated L/P and L/Glc ratios.
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"The improvement that we have seen in impairment reflects the signs of economic recovery now evident in many of the markets in which we operate," John Varley, the chief executive, said in a statement.
It is thought that this impairment reflects both a reduced capacity to synthesize new tissue and the antagonistic activities of high levels of proteinases within the chronic wound environment.
Thus, their impairment reflects impulsive choice rather than perseveration to a particular visual cue or direction or movement.
Renal impairment reflects the filtration capacity of the kidney, and albuminuria is associated with kidney disease and generalized vascular inflammation.
All these studies and recently published guidelines for drug dosing in renal impairment reflect on our daily clinical practice in a hospital care setting.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com