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► Correlations occur with motor impairment off medication.
This pattern of impairment off medication and improvement on dopaminergic therapy in PD is the signature of a DS-mediated function.
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Alternatively, this approach can be used to estimate the cognitive impairment of off-target pharmacology of other types of medications targeted at positive and negative symptoms in Schizophrenia total.
Time perception impairments OFF medication were also associated with abnormal cortical and cerebellar activity.
The AMPA receptor blockade led to a strong impairment of typical OFF-pathway functions like color vision and the cone ERG.
The diagnosis of autistic disorder was made using the Autism-Diagnostic Interview-Revised (ADI-R; Cut-offs: Impairment of Social Interaction = 10; Impairment of Communication = 8; Stereotyped Behavior = 3) and the Autism Diagnostic Observation Scale (ADOS, Cut-offs: Communication and Social Interaction = 7 (Module 1), 12 (Module 2), 10 (Module 3+4)) [ 29- 32].
To assess cognitive impairment after off-pump coronary-artery bypass grafting, with a particular emphasis on long-term follow-up and related risk factors.
Visual impairment: cut off at visual acuity less than 0.4.
Within each RECPAM class, the AUC ranged from 0.64 in class I with the highest executive cognitive impairment (cut-off score of 16.5) to 0.82 in class 4 with the lowest executive cognitive impairment (cut-off score of 17.5).
It is possible that mild PD subjects might display impairments when off medication, but this was not determined because the design of the study was such that all subjects were on medication.
Higher scale scores (ranging from 0 to 24) stand for greater functional impairment (cut-off ≥ 7; [ 14]).
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