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Although initially designed for respiratory failure, venoarterial extracorporeal membrane oxygenation (VA ECMO) has become a mainstay of therapy in the treatment of patients with congenital heart disease, providing preoperative and postoperative support for infants with temporary impairment of myocardial function.
Such primary diagnosis of CAD by MRI and/or CT can utilise different strategies: detection of coronary calcifications; imaging coronary artery stenoses; and detection of a reduced coronary perfusion reserve (resulting in restricted myocardial perfusion with or without impairment of myocardial function).
The common final path is an impairment of myocardial function.
This could support the conclusion that impairment of myocardial function can occur without myocardial ischaemia in the acute phase.
In consequence, both TDI- and STE-derived LV peak strain and strain rate during bicycle stress echocardiography are a useful tool to detect early impairment of myocardial function due to longstanding arterial hypertension.
Impairment of myocardial function after burn and smoke inhalation injury is characterized by an activation of the p38-mitogen-activated protein kinase pathway, myocardial neutrophil accumulation and increased nitric oxide production.
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This impairment is linked to deficient length-dependent regulation of myocardial function [ 13].
Furthermore, TDI offers more direct evaluation of myocardial function.
Rats were terminated after analysis of myocardial function.
Therefore, the LV systolic dysfunction observed in the DM and DM + MI groups cannot merely be the result of the much reduced heart rate and instead points to greater impairment of myocardial contractile function.
Engelhardt et al. have shown an impairment of myocardial contractility associated with impaired Ca2+-handling in β1TG mice [ 11, 12].
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