Sentence examples for impairment of hepatic function from inspiring English sources

There was also a significant increase in alanine transaminase concentration [+12.8 3.1) IU/L], an initial indicator for a functional impairment of hepatic function with non-alcoholic fatty liver disease [ 37].

Fulminant hepatic failure is clinically characterised by acute severe impairment of hepatic function, causing hepatic encephalopathy within 8 weeks of jaundice [29].

This could at least in part explain the findings of early impairment of hepatic function in clinical sepsis.

The lack of increase in hepatic lactate uptake in peritonitis may be related to either the relatively modest increase in portal venous lactate, to sepsis-induced impairment of hepatic function unrelated to tissue perfusion, or to a combination of the two mechanisms.

DSePA inhibited radiation-induced hepatic lipid peroxidation, protein carbonylation, loss of hepatic function, and damage to the hepatic architecture.

ICG clearance is frequently used as global marker of hepatic function as it illustrates hepatic purification and also hepatic blood flow [11].

These approaches allowed us to analyse sepsis-associated impairment of hepatic excretory function, demonstrating potential implications for the clinical setting.

Our findings of a sepsis-associated impairment of hepatic excretory function specifically at the canalicular pole support and strengthen recent reports about mechanisms of a disturbance of the hepatocellular transport machinery in early sepsis.

Patients had histologically confirmed, inoperable locally advanced or metastatic colon cancer progressing after a minimum of one line of therapy with at least one measurable lesion, age ⩾18 years, life expectancy ⩾12 weeks, World Health Organization performance status of 0 1 and no impairment of hepatic or renal function.

Studies of filgrastim in patients with severe impairment of renal or hepatic function have shown it exhibits similar pharmacokinetic and pharmacodynamic profiles to those seen in normal individuals; therefore, it is not necessary to modify the Nivestim™ dose in patients with renal or hepatic dysfunction [ 40].

Toxicological studies in animals confirmed that the major toxicities of this compound were myelosuppression, diarrhoea, and transient impairment of renal and hepatic function.