Effects of diabetes on cardiac function were characterized, inter alia, by substantive impairment of functional indexes including LVEF, CO/LVM (a measure of myocardial efficiency [ 30, 33]), LVEDV/LVM, LVESV/LVM, stroke volume/LVM and elevated LVM/BW (the latter a measure of relative LV hypertrophy).
Alternatively, the diffusion changes seen on MRI might not be directly related to histopathology, but could be due to prion disease causing impairment of functional processes in brain cells, such as altered ion channel function due to decreased plasma membrane fluidity (DeArmond et al., 1996) or impaired axonal transport (Liberski and Budka, 1999).
Although delirium is known as a mental disorder, recent evidence suggests that it is associated with short- and long-term impairment of functional status.
Conceptually, the antisense approach represents an elegant strategy, involving the targeting to and association of an ODN sequence with a specific mRNA via base-pairing, resulting in an impairment of functional and/or harmful protein expression in normal and diseased cells/tissue, respectively.
Conclusion ICU stay was associated with a significant impairment of functional autonomy in this cohort of patients admitted to a Tunisian ICU.
However, impairment of functional p53, either by mutation or loss of expression, is frequently detected in cancer.
The report from the Consensus Development Conference on Diabetes and Older Adults convened by the American Diabetes Association provides a framework for differentiating treatment goals in the older patient based on health status (presence and number of comorbidities or impairments of functional status).
Sixty-one per cent of these survivors had no impairment of their functional status.
A useful interpretation perhaps is to consider that an adverse effect results in the impairment of the functional capacity of the organism or higher levels of organization.
