The expression of collagen VI chains is highly regulated at different levels such as gene transcription, processing of encoding RNAs, efficiency of translation and post-translational modifications [22], and the impairment of the efficiency of each step may affect protein assembly and secretion.
Alveolar hypoperfusion, caused by impaired or defective vasodilation, probably represents the link to the impairment of ventilatory efficiency.
This reduces the energy demand but not enough to balance ATP production and utilisation, due to the impairment of mechanical efficiency with fatigue.
Interestingly, in vitro extended culturing of neurospheres from EAE mice with FGF-II and EGF for a total of 10 passages of amplification completely reversed the impairment of clonal efficiency observed in primary and secondary neurospheres (Fig. 5B).
This relates to the dynamic developmental theory of Sagvolden et al., which concentrates on the registration of reinforcement and related motivational consequences, in particular, a mesolimbic impairment of the "efficiency with which the contingency between present action and future rewards is signalled".
Changes in the UCH-L1 (a protein that recycles free ubiquitin) activity may result in an impairment of the efficiency of the ubiquitin-proteasome system (Osaka et al., 2003; Li et al., 2004) which is involved in PD (Leroy et al., 1998).
We also compared total ion current (TIC) chromatograms because a general impairment of the ionization efficiency would be expected to become apparent as depressed TIC.
Impairment of RV-PA coupling efficiency was observed only in SU_M.
Increased E a combined to altered E es in male rats resulted in impairment of RV-PA coupling efficiency, while ventricular-arterial coupling was preserved in the SU_F group.
Since we used a modified model of angioproliferative PH combining semaxanib injection in athymic nude rats under normoxic conditions [ 6], animals were thus exposed to a strong angioproliferative stress resulting in impairment of ventricular-arterial coupling efficiency, pleuropericardial effusion, and sudden death in males.
