An unstable system is sensitive to perturbation or noise, and it will have erratic behaviors, possibly causing irreparable cell damage, leading to impairment of cell functions and maybe even cell death.
These results suggest that the MINC assay specifically detects impairments of cell function that are not detectable by other assay systems.
Although it is clear that diabetes induces the impairment of satellite cell function, understandings of the molecular mechanisms remain insufficient.
The mechanism has been explained by the induction of cellular differentiation and impairment of stem cell function by decreased methylation due to reduced expression of Dnmt1 [ 141, 145].
Possible causes include mild hypogonadism secondary to chemotherapy-induced impairment of Leydig cell function, a direct effect of chemotherapy on bone, an effect of high-dose glucocorticoid on bone or an effect of Hodgkin's disease per se.
Osteomyelitis is common in patients with osteopetrosis because of a reduced resistance to infection, attributed to the lack of marrow vascularity and impairment of white cell function.
Postoperatively there was an increased risk for osteomyelitis attributed to the lack of marrow vascularity and impairment of white cell function and longer surgical time.
A transient elevation of IL-6 leads to satellite cell proliferation, whereas a chronic elevation of IL-6 induces the impairment of satellite cell function [ 137].
Since the early 1980s, many studies have documented decreased NK cell numbers and impairment of NK cell function in the peripheral blood of patients with autoimmune diseases such as multiple sclerosis (MS), systemic lupus erythematosus (SLE), Sjögren's syndrome, rheumatoid arthritis (RA), and type I diabetes (reviewed in [ 24- 26]).
It is not clear whether this cell death results from synaptic defects or from some other impairment of Müller cell function, but the non-cell-autonomous nature of this degeneration is notable.
Less epithelial cell proliferation was observed in adult PTM-ARKO SVs, compared with controls, and production of seminal proteins was reduced, indicating global impairment of epithelial cell function in PTM-ARKO SVs.
