During aging, adult tissue stem cells exhibit impairments in functionality and exponential increases in premalignant mutations driven by cell-intrinsic defects and alterations in the stem cell niche and the blood circulatory environment (Ju et al., 2007; Behrens et al., 2014).
We assessed the impact of sarcopenia on impairment in both aspects of functionality and the relative contribution of its components, muscle mass and strength.
Improved knowledge of the specific mechanisms that mediate impairments in physical functioning, especially the relevance of functionality tests (gait speed versus mobility), based on demonstration of strength and muscle power, are crucial for developing effective interventions for preserving mobility and independence among older people [ 8, 12].
Interventions designed to prevent sarcopenia and improve muscle strength may help reduce the burden of cognitive and physical impairments of functionality in community-dwelling seniors.
I'm more interested in functionality".
It's too limited in functionality.
Although the elevated levels of fasting glucose and impairment of insulin action in peripheral tissues may predate the diagnosis of type 2 diabetes, chronic hyperglycemia only results after a prolonged period of β-cell degeneration, a process that may begin as much as 12 years before diagnosis, involving a progressive reduction in functionality and mass (1, 2).
This finding suggests that the amount of this proteoglycan in urine, as well as proteinuria, could represent an early biomarker of renal impairment in Fabry's patients, useful in monitoring renal functionality also in those patients without overt renal damage.
However patients display impairment in sound transduction capabilities, and also how we demonstrated now, in vestibular functionality.
However, the impairment in the material properties of bone tissue secondary to gamma radiation sterilization is a concern since the mechanical functionality of a bone graft is of primary importance.
