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Functional impairment was defined as having difficulty with one or more Activities of Daily Living [ADLs - bathing, dressing, feeding, toileting or transferring]); mobility impairment (difficulty walking several blocks); hearing impairment (a response of "poor" or "fair" to "Is your hearing excellent, very good, good, fair or poor?").
Severe generalized dystonia is frequently a prominent symptom and can be very disabling, causing gait impairment, difficulty with speech and swallowing, pain and respiratory distress.
Severe generalized dystonia is frequently a prominent clinical symptom of NBIA, which can be very disabling and cause gait impairment, difficulty with speech and swallowing, pain, respiratory distress and, in some cases, death due to dystonic storm, respiratory failure or infection.
1 2 The typical pathological characteristics of AD are degeneration of specific nerve cells, presence of neuritic plaques and neurofibrillary tangles. 1 People with AD experience memory loss, cognitive impairment, difficulty communicating and mood changes, all of which will worsen over time.
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Cognitive impairment, difficulties in relationships, and social and occupational functioning also often persist during clinical remission (Giglio et al. 2010).
AD is characterized by general cognitive impairment, difficulties with memory consolidation and retrieval, and with advanced stages episodes of agitation and anger.
1– 3 In terms of the type of behavioural difficulty associated with hearing impairment, difficulties related to attention have been specifically noted.
However, it is well known that many patients are unable to assess their own QoL and complete a QoL measure because of cognitive impairment, difficulties in communication, symptom-related distress, or complexity of QoL measure.
That means that there is finally a therapeutic target for a disorder defined by behavioral criteria like social impairments, difficulty communicating and repetitive behaviors.
3 Older cancer survivors may be predisposed to falls because cancer- and treatment-related side effects impact virtually all body systems. 2 Pain, fatigue, muscle weakness, vision and cognitive impairments, difficulty with balance and walking can emerge while a person is receiving cancer treatments or develop years after treatments have completed.
Concept elicitation interviews identified functional concepts of impairment including: difficulty performing tasks; difficulty related to interactions; and feelings of stress about difficulty with school work and performing tasks.
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