In the following review, common aspects of mitochondrial impairment concerned about neurodegenerative diseases are summarized including ROS production, impaired mitochondrial dynamics, and apoptosis.
This impairment concerned the recognition of the facial emotion expressions disgust, fear and anger.
Almeida and Flicker [ 2] presented in their review several reports on the role of congestive heart failure in a generalized cognitive impairment, concerning memory and attention deficits.
Patients could be included if they were 65 years of age or older, lived at home or in a non-medical institution, volunteered to participate to a periodic health examination and if a memory impairment concern was identified (either by the patient themselves or by a member of their family).
Consistently reported impairments concern fragmented sleep, hyper-arousal and executive dysfunction.
Concerning the neuropsychological profile, the subtest analysis of the Wechsler IQ test showed impairments concerning processing speed and visual motor skills.
In addition, administrating the GDS-15 as an interview facilitates the completion of the questions for people with impairments concerning, e.g. vision.
At the beginning of the disease process patients display deficits of planning and strategical thinking, whereas in chronic patients this shifts towards impairments concerning categorization and flexibility as assessed by the WCST.
Visuospatial impairments concerning the left hemifield are represented by a relative preponderance of omissions and higher reaction time values in the left visual field compared to the right visual field, which results in positive values when calculating left minus right visual field performance.
Hence, cobicistat can be administered in patients with liver impairment without concerns regarding safety and efficacy.
