Sentence examples for impairment accumulation from inspiring English sources
In case of autophagy impairment, accumulation of p62 and the subsequent overactivation of Nrf2 may contribute to development of liver carcinomas [ 96].
Side LED trials were unimpaired (p > 0.5; Figure 3B), indicating that the impairment on accumulation trials was not simply a motor effect.
(B ) Bilateral infusion of muscimol into the FOF results in a substantial impairment on accumulation trials but has no effect on side LED trials.
We used the CAG140 140-glutaminee CAGon (CAG)) knockin mouse (CAG140KI) to model HD, which exhibits slowly progressing neurobehavioral impairments and accumulation of large HTT neuropil aggregates [ 114].
This suggests that the genetic defects in mitochondria activate a metabolic checkpoint, producing autophagy impairment and mitochondrial accumulation that limit tumor progression, revealing a novel tumor-suppressive mechanism for mitochondrial inhibition with metformin.
The cDDP-resistant phenotype seems, at least in part, to be involved in the action of these compounds, since the level of cross-resistance established for most complexes appeared to be in agreement with the observed impairment of drug accumulation in the resistant subline.
However, impairment of fat accumulation cannot be excluded.
The neuronal ceroid lipofuscinoses are heritable lysosomal storage diseases characterized by progressive neurological impairment and the accumulation of autofluorescent storage granules in neurons and other cell types.
In conjunction, these studies suggest that the relationship between CNS insulin impairment and AβO accumulation in the brain is rather complex and should be evaluated in future studies.
Despite the severe impairment in SA accumulation within the first 12 hours post-inoculation of ndr1 plants, bacteria carrying avrB could nonetheless induce PR gene expression and SAR because of the HR-associated pathway.
Until recently, studies of NPC1 gene function have been mostly focused on the pathogenesis of the CNS disease even though that is a secondary neurological impairment of lipid accumulation.
