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To organisms that rely on chemical signals to make crucial ecological decisions, increased amounts of a pollutant may impact chemoreceptive abilities by altering the perception of the sensory landscape or impairing the functioning of sensory organs.
For instance, sorrow involves a bodily change for the worse, depressing the spirits and the movements of the heart, prompting uncomfortable shifts in body temperature, and generally impairing the functioning of the body.
We see that lead has the potential to impact individuals' functioning across a wide variety of domains, with the ultimate effect of impairing the functioning of society.
This process may also be amplified by UV exposure, impairing the functioning of biomolecules and eventually leading to less firm and less elastic skin that is more prone to wrinkling.
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A measure of the selective pressure acting on exons is the ratio of non-synonymous (potentially impairing the function of the gene) over synonymous (neutral) mutations.
Consistent with this idea, we observed a reduction of a sign of DNA damage, dead stem cells, after impairing the function of BRM in the rpt5a mutant under normal B conditions (Fig. 7c).
In addition, old SCCs showed a higher ratio of non-synonymous (potentially impairing the function of the gene) over synonymous (neutral) mutations (Fig. 2d), meaning a higher number of potentially deleterious mutations compared to young SCCs.
Given the excessive accumulation of LDs in lysosomes2,4,5,26, they may exert membrane fluidization, hence impairing the function of central lysosomal membrane residents or protein complexes associated to the lysosomal membrane like mTORC1.
Tumor-derived EVs can contribute to creating an immunosuppressive microenvironment by impairing the function of immune cells.
The progressive abnormal hypertrophy may result in degradation of the matrix, impairing the function of the repair tissue.
By impairing the function of the upper oesophagus sphincter, it may facilitate the reflux of bacteria from the gut.
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