Sentence examples for impairing the binding from inspiring English sources

It is most likely that the shift affects the three-dimensional structure of the protein, impairing the binding capabilities to the other proteins in the complex.

Compared with Fe2+, the native cofactor of JHDMs, Ni2+ can stabilize JHDMs without impairing the binding of JHDMs with its ligands.

We proceeded to investigate whether ORF73 would be functioning at the nuclear level by impairing the binding of NF-κB to DNA κB sites.

These findings suggest that PDB-related SQSTM1 mutations may confer a higher susceptibility to development of the disease by impairing the binding of the p62 protein to a ubiquitinated target.

The possible inhibition mechanisms could be due to altering the distances between the glycans present in the E glycoprotein and impairing the binding to the DC-SIGN receptor [ 112].

Increase/decrease in the number of cytosine residues in the poly-C region may affect the rate of DNA replication by impairing the binding of polymerase and other trans-acting factors (Fliss et al, 2000).

MDV3100 also reduces the efficiency of AR translocation to the nucleus and impairs the binding of AR to the androgen response element and other factors that bind to AR [ 99].

Mutations of the two Cys residues can significantly impair the binding ability of hCutC with Cu(I).

Moreover, we show that the association of NP with the host transporter does not impair the binding of NP to RNA.

In contrast, the AA →Glu mutations of the hydrophilic residues Gln148, Lys156 and Lys159, known for their interactions with LTRs (long terminal repeats) and inhibitors (5 CITEP, for instance), significantly impaired the binding of K156 to the antibody.

We found that HbF impairs the binding of parasitized RBCs to human microvascular endothelial cells (MVECs), monocytes, and nonparasitized erythrocytes – cytoadherence interactions that contribute to the development of high parasite densities and the symptoms of malaria.