This study showed for the first time that even weak correlations can impair stimulus encoding in the form of firing rates in an ensemble of neurons.
We further examined individual differences in human discriminative fear learning and tested whether successful versus unsuccessful discriminative startle potentiation would be reflected, respectively, in normal versus impaired stimulus differentiation within the amygdala.
This indicated that, in addition to altering triad organization in zebrafish muscle, DNM2-S619L expressimpairsairstimulus-associateded intracellular calcium release, a triad-mediated muscle function.
Disruption of the WFS1 gene in mice causes progressive β -cell loss in the pancreas and impaired stimulus-secretion coupling in insulin secretion.
While there is good evidence that islet insulin staining (aka content) decreases with time, the relative contributions of decreased insulin content, fewer β-cells and impaired stimulus-secretion coupling to reduced insulin secretion in T2D is still uncertain.
Yin also found that face recognition was disproportionately impaired by stimulus inversion when compared to recognition of other objects.
At the postsynaptic level, intra-accumbens or systemic administration of dopamine D1 receptor blockers impairs simple stimulus-reward learning [ 87] that engages dopamine neurons, well distinguished from performance [ 88 ].
An earlier study demonstrated that the benzodiazepine receptor agonist chlordiazepoxide (CDP), when administered before the phase of preexposure to the to-be-conditioned stimulus, impaired animals' ability to develop LI.
Evidence of selective impairments in blue-yellow but not red-green color perception would mitigate an alternative explanation that impaired perception of stimulus color reflects an attention dysfunction, and be consistent with the proposed hypothesis that dysregulation of central and retinal dopamine impairs blue-yellow color perception.
Despite the caution expressed by the Treasury, the Institute for Fiscal Studies said that the chancellor could provide the economy with a stimulus without impairing the government's credibility in the financial markets.
Here, we have shown that when RPE cells are subjected to sustained wound stimulus by impairing the establishment of cell-cell contacts, there is a self-perpetuating activation of TGFβ pathway that persists even after a confluent monolayer is reestablished.
