Sentence examples for impairing its function from inspiring English sources

Mutations within the DNA binding domain (DBD) of the tumor suppressor p53 are found in > 50% of human cancers and may significantly modify p53 secondary structure impairing its function.

These fusions are expected to disrupt clathrin trimerization, thereby impairing its function during mitosis [5].

Also these latter fusions are thought to disrupt clathrin trimerization, thereby impairing its function during mitosis [5].

They also discovered that urokinase plasminogen activator undergoes truncation between domains 1 and 2, thus impairing its function.

Poorly controlled norepinephrine release could also give rise to excessive activation of α1-adrenoceptors in the prefrontal cortex impairing its function.

The MDM2 binding domain overlaps with the transcriptional activation domain of p53, and therefore MDM2 binding also inhibits the transcriptional activity of p53, thus effectively impairing its function [ 18].

The information in question was held to be freely translatable from one "coding" to another without impairing its functions.

Unlike a healthy heart with isolated conduction disturbances, in which suboptimal efficiency may impair its function but not lead to impairment of physical capacity or survival, the dilated failing heart may be operating on a knife-edge in which even apparently minor inefficiency is compounded by adverse feedback processes in a way that impairs capacity and worsens survival.

Since the APOA5 −1131T>C polymorphism is located in the promoter region of APOA5, it may alter the APOA5 expression and impair its function, and cooperative effects between APOA5 polymorphisms cannot be excluded.

The presence of pericardial fluid in excessive amounts may enlarge the silhouette of the heart in X-rays but not impair its function.

Radiation-induced changes in the physical properties of a packaging material and medical plastics should not impair its function and the degradation products as well as the utilized additives should be non-toxic [6].