Sentence examples for impairing activity from inspiring English sources

Furthermore, this impairing activity was not dependent on TDP-43 aggregation.

In these cells, neurite growth was impaired (Fig. 5B, black bars), suggesting that for these N-terminal fragments the impairing activity for neurite growth depends on their aggregation.

In addition to impairing activity, some mutated forms of pol β can have additional consequences resulting from nonproductive binding of damaged DNA intermediates or the displacement of native, wild-type pol β from DNA repair complexes.

In addition, the C1a Asp424Ala mutation (analogous to the αGC Asp514Ala mutation) severely impaired activity and activation.

Likewise, mild fatigue may have a multiplicative effect in impairing activities of daily living in a frail older woman, while only being bothersome to a younger woman.

Muscle atrophy and weakness impair activity of daily living (ADL).

Yet the human Met carriers also exhibited impaired activity in the prefrontal cortex, a region important for extinguishing fearful associations.

However, this alteration is insufficient to account for the neurite growth-impairing activity of the TDP-43 fragments.

This may result in a non-functional or a protein with abnormal function ultimately resulting in impaired activity in splicing.

Interestingly, this pathway is disturbed in ccRCC [43] and thus may possibly contribute to impaired activity of splicing factors.

Although the tagged protein (Hes7BAP) retains wildtype-like repressor activity in cultured cells (Figure 5A), it shows greatly impaired activity in vivo.