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The presence of autoantibodies against human neuronal progenitor cells suggest an impaired tolerance to neural antigens in autism.
In autoimmune rheumatic diseases, impaired tolerance leads to the development of diseases such as rheumatoid arthritis, systemic lupus erythematosus, and Sjogren's syndrome.
This chronic activation of the innate immune system can lead to insulin resistance (IR), impaired tolerance to glucose and, eventually, T2DM [ 8],[ 9].
In this phase before the initial psychotic episode, many symptoms may be present, including depressed mood, anxiety, irritability, changes in volition, cognitive changes, physical symptoms, behavioural changes, impaired tolerance to normal stress, and attenuated psychotic symptoms.
Consistent with mild ∼4-fold, overexpression of miR-184, Keto mice exhibited reduced insulin levels and impaired tolerance compared to control mice after a glucose challenge; however, no change was observed in β cell mass.
For decades, high physical capacities have been considered important for preserving work ability among workers with high physical demands [ 54], and workers with low muscular strength of the trunk and neck/shoulder region are considered to have an impaired tolerance for physically heavy work [ 45, 55].
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We encourage further research on utility weights of normal glucose tolerance, impaired glucose tolerance and type 2 diabetes mellitus.
Of the 1,071 adults with normal glucose tolerance or impaired glucose tolerance (IGT) at baseline, 906 returned for follow-up.
Subjects were identified as normal glucose tolerance (NGT), impaired glucose tolerance (IGT), or CF related diabetes without fasting hyperglycemia (CFRD FH−).
24.4% of patients showed normal glucose tolerance, 29.4% impaired glucose tolerance and 46.2% diabetes mellitus.
Annual oral glucose tolerance test monitoring highlighted gradually worsening glucose tolerance (impaired oral glucose tolerance test).
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