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The titer of the control vector RSC-SMPGW was slightly decreased (13%), suggesting the rev mutation minimally impaired the efficiency of lentiviral vector production.
The main finding of this study was that prolonged endotoxemia impaired the efficiency of hepatic mitochondrial complex I and complex II respiration, whereas mitochondrial respiration in the skeletal muscle remained unchanged.
Substitution of these residues by glutamic acid (E) and threonine (T), the respective amino acids present in related HD-containing transcription factors such as Bsx and Msx1, significantly impaired the efficiency of reprogramming in both Nanog /– somatic cells and wild-type EpiSCs (Fig. 4F-I; supplementary material Fig. S3G).
Nonetheless, TFP significantly retarded the resolution of γH2AX and recovery of proliferative capacity in U1810 and H23 cells after DNA-damaging treatment, suggesting that TFP somehow impaired the efficiency of DNA repair and/or prevented the inactivation of signals that maintain cell-cycle checkpoints.
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On the other hand, the presence of a few insufficient cycles, as shown in Fig. 3, does not drastically impair the efficiency of ventilation, as the patient receives at least nine efficient insufflations in the one-minute period.
This will ensure that any chlorine added will work more efficiently - high pH levels in particular will impair the efficiency of the chlorine doing its job.With the pool filter system running, add a chlorine based swimming pool shock at the rate of 1 lb.
"Our decision cannot turn," Justice Scalia wrote, "on whether or to what degree trial by jury impairs the efficiency or fairness of criminal justice".
Four hundred elements were found to give sufficient accuracy without impairing the efficiency of the solution method.
Previous analyses of partially methylated viral reporter constructs demonstrated that methylation of genes within promoter-proximal regions and transcription start sites impair the efficiency of transcription initiation [18].
These conditions could potentially impair the efficiency of the immune response in clearing the infection.
For several genes we detected additional polymorphic sites within 60 bp of the position used for mapping, without impairing the efficiency of the capture.
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