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In addition, experiments using T cell co-cultures demonstrated that the vhs protein impaired the development of Th1 immunity as shown by the impairment in the expression of a number of Th1-related genes.
Mutants of JAM-A which were designed to mislocalize strongly impaired the development of cysts and the formation of functional tight junctions.
We found that hjv is strongly expressed in the notochord and somites of the zebrafish embryo and that morpholino knockdown of hjv impaired the development of these structures.
Truncation of the deubiquitinating domain of CYLD specifically in myelomonocytic cells impaired the development of lethal LPS-induced endotoxic shock and the accumulation of thioglycollate-elicited peritoneal macrophages.
These results indicated that, in contrast to the complete depletion of PGCs seen in male mutant mice [28], the Separase mutation only partially impaired the development of female PGC, resulting in deficient initial follicles but not in complete PGC depletion.
Moreover, reversion of epithelial characteristics to a mesenchymal morphology (spindle-like fibroblastic cell shape) by silencing the fibroblastic growth factor receptor IIIc subtype (FGFR2IIIc) impaired the development of metastases and increased mouse survival [46].
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In addition, chronic stress during childhood impairs the development of the ability to delay gratification.
We investigate whether oxidative stress induced by postnatal hyperoxia impairs the development of the cerebellar white matter.
Thus, social isolation early in life can impair the development of squamate reptiles, as it does in mammals and birds.
So, living in an adverse environment could impair the development of primaries levels and it would impact in the development of superior levels (Stuss 1992).
Microangiopathy further reduces vascularisation and impairs the development of collateral vessels in ischaemic tissues and thus amplifies the severity of macroangiopathy, promoting tissue hypoxia and reduced wound healing.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com