Sentence examples for impaired stimulation from inspiring English sources

The result showed that BMSCs from GE P−/ mice displayed impaired stimulation of osteoblastic marker genes following BMP2 treatment, suggesting that GEP directly participates in BMP2-induced osteoblastogenesis.

However, since there are relatively few cells in the degenerated IVD and cell viability is impaired, stimulation of the remaining cells may be insufficient to achieve repair [ 13].

Clinical-grade tolDCs established from patients with RA exhibit a typical tolerogenic phenotype of reduced costimulatory molecules, low production of proinflammatory cytokines and impaired stimulation of autologous antigen-specific T cells, comparable to HC tolDCs.

Some authors have found faulty responses to general PRR stimulation including decreased IFNα and IL12 secretion, reduced CD86 expression, decreased HLA-DR (MHC class II) and impaired stimulation of T cells in mixed lymphocyte reaction compared with normal controls.

This is supported by data from dynamin I-deficient mice that exhibit impaired stimulation-dependent synaptic vesicle recycling [24].

This is supported by data from dynamin I-deficient mice that exhibit impaired stimulation-dependent synaptic vesicle recycling and the requirement of dynamin for SVE during periods of high neuronal activity [24].

Thus, we propose that lowered Abcc8, which would tend to raise the resting plasma membrane potential at low glucose while impairing stimulation by the sugar (Nenquin et al., 2004), combined with suboptimal increases in ATP/ADP ratios, alters β cell membrane excitability.

Production of IL-1β and of IL-6 was impaired after stimulation with LPS and with heat-killed bacteria but not after stimulation with Pam3Cys and PHA.

Since the transcription factor NFκB plays an important role in the induction of IP-10 expression [31], we investigated whether NFκB signaling might be impaired by stimulation of IEC with L. casei.

We wondered if the impaired immune stimulation of our pbMEC cells by S. aureus applied in SM10 might be due to FCS-mediated impaired ligand recognition by the TLR2 receptor.

In the latter study, the authors detected a slight down-regulation of CD40 and MHC class II molecules on DCs, suggesting that impaired co-stimulation by DCs from treated mice could contribute to peripheral T cell anergy.