Sentence examples for impaired stem from inspiring English sources

Hair growth requires functioning stem cells, suggesting these animals may have impaired stem cell regeneration, which can promote premature senescence (Figure 4F) [33].

Additionally, mice with conditional brain-specific deletion of Fbxw7 exhibit severely impaired stem cell differentiation and increased progenitor cell death.

Tcf-3/Tcf-4 double conditional-null mice, indeed, display defects in epidermal homeostasis with the absence of hair coat, aberrant HFs and impaired stem cell maintenance.

Furthermore, the numbers of expanding and committed cells increased in Ku80 heterozygous and null muscles suggesting impaired stem cell self-renewal (Fig 3B).

Dyskeratosis congenita (DC) is a genetic disorder of defective tissue maintenance and cancer predisposition caused by short telomeres and impaired stem cell function.

For example, defects in dorsal hair regrowth in ankyrin-B+/− mice (Figure 4D) are indicative of impaired stem cell regeneration.

Moreover, the authors describe evidence that telomere dysfunction impairs stem cell function by inducing cell intrinsic checkpoints as well as environmental alterations.

The mechanism whereby DM impairs stem cell mobilization may depend on altered local concentrations of the chemokine SDF-1α.

These data confirm that Dido3 ablation impairs stem cell differentiation already at the onset of primitive endoderm formation.

DOI: http://dx.doi.org/10.7554/eLife.07025.013 10.7554/eLiFigure25.014 figure 4—figure supplement 1. mex3-1 RNAi depletes progeny without impairing stem cell proliferation.

While alkylating agents that can impair stem cell mobilization are rarely used currently as part of initial therapy in transplant eligible patients, newer drugs such as lenalidomide can also impair the collection process.