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Decreased activity of the low ACCG haplotype was attributed to low translation of the protein, while the decreased activity of the ATCA haplotype was attributed to impaired stability of the protein as a result an amino acid substitution at SNP rs4680[33].
In knee osteoarthritis (OA) a substantial risk factor is impaired stability [ 1].
Impaired stability in the joint causes pathologies in the joint because of insufficient support of the collagen connective tissue in the nonjoint [ 4, 5].
A significant negative effect on the biomechanical characteristics with an impaired stability is detected after adding tigecyclin to polymethylmetacrylate-bone cement with a percentage of 1.225% per weight.
Impaired stability is a risk factor in knee osteoarthritis (OA), where the whole joint and not only the joint cartilage is affected.
Even though the release of CK from muscles is not a direct indicator of the damage to muscle structure, it is considered an adequate indicator of impaired stability of the muscle cell membrane [ 4].
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We have previously shown that the absence of this C-terminal tail does not impair stability and targeting into the chloroplast [15].
Predisposing risk factors are the intrinsic characteristics of the person that chronically impair stability and may make them more easily fall.
For example, an acute febrile illness, such as a community acquired pneumonia or a urinary tract infection, may precipitate a fall by impairing stability and decreasing one's ability to maintain the intricate balance needed to avoid a fall (Tinetti et al 1988).
Impaired temporal stability and poor motor unit recruitment are key impairments in Parkinsonian motor control during a whole spectrum of rhythmic movements, from simple finger tapping to gait.
Removal of hydrogen bonds impaired thermal stability, increasing the initial weight-loss rate from 0.025 to 0.036 wt%/hour.
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