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The increase in FFA and PAI-1 concentrations is more informative regarding impaired sensitivity to insulin in MI as compared to postprandial glucose and insulin levels.
If the CB dysfunction occurs in patients with ischemia or hypoxia-related illness, then impaired sensitivity to hypoxia and further failure to reduce metabolic oxygen demand in conditions of low O2 might promote mortality.
However, data to support this approach are lacking, and misclassification could occur both early in acute infection (impaired sensitivity because antibody is not yet present) and later (impaired specificity because antibody is persistent).
An affected breathing pattern per se is a rather unspecific finding, which could be due to several factors, (1) altered central breathing control, (2) impaired sensitivity of peripheral chemoreceptors, (3) altered respiratory muscle function, or (4) affected respiratory function per se.
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Requiring a higher cutoff titer would further impair sensitivity.
Multiple-testing correction is not a good option because it impairs sensitivity greatly.
Highly phosphorylated Smad3L is likely to impair sensitivity to growth inhibition by pSmad3C in tumor cells (48– 51).
Importantly, we did not find a relation between disease activity and in vitro GC sensitivity, suggesting that the impaired GC sensitivity is not just due to increased levels of proinflammatory cytokines.
It was reported not only that the resistin had no effect on insulin sensitivity of skeletal muscles [ 2, 20] but also that the resistin impaired insulin sensitivity of myocytes [ 3, 21, 22].
Results showed that multiple layers of gloves impaired haptic sensitivity.
Impaired baroreflex sensitivity (BRS) is associated with cardiovascular diseases and the metabolic syndrome.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com