Sentence examples for impaired preference from inspiring English sources

Conversely, Eif4e ki and Mnkhet mice display impaired preference for social novelty, as compared to wild-type mice.

Additionally, we confirmed that the rescue effect was not male specific because also in female Fmr1 −/− mice genetic reduction of eIF4E phosphorylation corrected impaired preference for social novelty.

This impaired preference for a novel mouse could indicate an inability to discriminate between familiar and novel mice, reduced interest in novelty, or other causes, but the interesting point is that this behavioral difference was shared between the Fmr1 knockout mice and the GSK3 knockin mice, which both share increased GSK3 activation levels in the brain.

Infusion of active MMP-9 but not of the proform was sufficient to block the rescue effects of chronic cercosporamide treatment in Fmr1 −/y mice, as demonstrated by the impaired preference for social novelty.

In agreement with previous reports (Bhattacharya et al., 2012), we noted an impaired preference for social novelty in the Fmr1 −/y mice, whereas WT mice clearly show a preference for the novel social stimulus (stranger 2), as compared to the original social stimulus (stranger 1; Figure 4F).

Nonetheless, it is interesting that Fmr1 knockout mice and GSK3 knockin mice share the phenotype of impaired social preference.

Since Fmr1 knockout mice exhibited impaired social preference (Fig. 2), we tested if this was also altered in GSK3 knockin mice.

Using the partition interaction test, with ovariectomized C3H female mice as the stimulus, this group reported that Fmr1 knockout mice exhibited deficient social interaction and impaired social preference [17].

These results are similar to those observed with the Fmr1 knockout mice, suggesting a possible correlation between less inhibitory serine phosphorylation of GSK3 and impaired social preference for a novel stimulus mouse.

The results indicate that GSK3 contributes to a subset of social behavioral deficits in Fmr1 knockout mice, including impaired social preference and increased anxiety-related behaviors during social interaction.

Some, but not all, previous studies have reported impaired social preference of Fmr1 knockout mice [12], [16], [19], with variations likely due to methodological and mouse strain differences [33].