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An additional putative cause for the observed increase in liver weights resulting from 2A-DNT dosing is impaired potential for lipid metabolism.
Because caffeine is frequently consumed and has a half-life of many hours, many patients entering the hospital with a myocardial infarction may have impaired potential to be protected by interventions, such as IPoC and drugs like statins and bradykinin.
Wilbanks et al. [ 15] indicated that the increases in carbohydrate metabolism occurred in 2,4-DNT exposures as a likely compensatory mechanism to maintain energy budgets given the impaired potential to utilize lipid as an energy substrate.
This is supported by the finding that the sperm of low-carotenoid diet males had a significantly lower antioxidant capacity (i.e. poorer reserves of functional antioxidants), and therefore impaired potential to scavenge reactive oxygen species (ROS) and mitigate the negative effects of oxidative stress (Velando et al. 2008).
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However, in pathological states such as muscular dystrophies, satellite cell number as well as their doubling potential are thought to decrease, resulting in impaired regenerative potential [3], [4].
In the aging heart, an impaired protein-kinase C translocation is one of the reasons responsible for the impaired preconditioning potential [ 32].
Unfortunately, they also show an unspecific cytotoxicity which has greatly impaired their potential clinical uses.
Observed effects in fish include intersex changes, impaired reproductive potential, and tissue accumulation of active substances.
The studs did not develop full flexural strength due to local buckling and this impaired their potential contribution to the story shear resistance.
In addition, reproductive tracts of females born from nanoselected spermatozoa showed no indication of impaired fertility potential, although a significant shortened uterine horn length was measured (56.3±2.6 cm vs. 64.4±2.2 cm in the control group, P=0.04).
Consistent with the defects in cell cycle progression and clonal expansion abilities, decrease in Ki67-positive cells was accompanied by misexpression of LAP2β and decreased expression of HP1α in WS-MSCs at passage 3 and further at passage 9 (Figs. 4F, 5A and 5B), indicative of impaired proliferation potential and heterochromatin disorganization since early passages.
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