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4 Malnutrition is associated with a decline in functional status, impaired muscle function, decreased bone mass, immune dysfunction, anemia, reduced cognitive function, poor wound healing, delayed recovering from surgery, higher hospital and readmission rate, and mortality.
Inadequate diet and malnutrition are associated with a decline in functional status, impaired muscle function, decreased bone mass, immune dysfunction, anemia, reduced cognitive function, poor wound healing, delay in recovering from surgery, and higher hospital and readmission rates and mortality.
The prevalence of malnutrition is increasing in this population and is associated with a decline in: functional status, impaired muscle function, decreased bone mass, immune dysfunction, anemia, reduced cognitive function, poor wound healing, delayed recovery from surgery, higher hospital readmission rates, and mortality.
Exercise-induced oxidative stress may initiate or accelerate impaired muscle function.
Such quantitative muscle loss is associated with an increased echogenicity, possibly associated with progressively impaired muscle function.
However, most patients still had impaired muscle function at the time of the second biopsy.
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Lactic acid can impair muscle function for awhile, preventing you from sprinting efficiently at the end of the race.
Among possibilities to explain ubiquitin ligase independent effect of RNF5 is that RNF5 may impair muscle function by squelching or recruiting components of the ER machinery, by outcompeting its associated ligases (i.e. CHIP or gp78), or by acting as an E4 ligase on specific substrates after their ubiquitination by another E3 for which ligase activity may not always be required (i.e. p300 [44]).
Moreover, IR may synergistically impair muscle function, since it is associated with decreased muscle strength, even in patients without overt DM [ 99].
The cytoplasmic Actinin2-rich aggregates were also positive for actin, suggesting they further deplete the sarcomeric pool of actin, and may impair muscle function in this way.
The low correlation between the severity of clinical muscle symptoms and inflammation and structural muscle fibre changes indicates that mechanisms other than direct cytotoxic effects on muscle fibres might impair muscle function.
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