Sentence examples for impaired lymphocyte function from inspiring English sources

Furthermore, impaired lymphocyte function probably occurs after CPB.

Thus, we investigated mechanisms involved in postoperative lymphopenia and impaired lymphocyte function after CPB.

3) To demonstrate that CPB impaired lymphocyte function (ability to proliferate).

In addition, critically ill patients commonly show marked apoptosis-induced lymphopenia and impaired lymphocyte function which contribute to sepsis- and injury-associated immunosuppression as recently reviewed elsewhere [37].

Most importantly, the authors suggest that impaired lymphocyte functions after sepsis could be reversible.

Likely mechanisms involve altered expression of key immune regulators, induced apoptosis, oxidative stress and inflammation in circulating PBMC, impaired lymphocyte activation and macrophage function, and altered cellular and humoral immunity (Table  1).

Chronic uremia leads to metabolic abnormalities that alter the immune response such that antigen-presenting cell (APC) function is impaired, lymphocyte survival is shortened, proliferation of T-cells is impaired, together with an increased suppressor T-cell activity, decreased helper T-cell (Th) activity, and increased Th1/Th2 ratio [ 2, 3].

In addition, different immunosuppressive cells such as MDSC or tumor-associated fibroblasts have been reported to impair T lymphocyte function through increased L-arginine catabolism [ 10, 37, 43].

Evidence indicates that impaired T-lymphocyte function contributes to the increased susceptibility to infection during the later phases of sepsis.

Unlike other immunosuppressants it does not impair lymphocyte proliferation, nor does it induce apoptosis of lymphocytes [ 4].

These findings exclude ASML-exosomes to impair lymphocyte activation due to active suppression.