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This finding of less complex dynamics in the BD group compared to controls is consistent with the loss of complexity hypothesis in disease and disorder [38], perhaps indicating weakened links between the sensorimotor systems, i.e., impaired integration of visual, vestibular, and proprioceptive systems, that form the critical feedback loops essential to the control of postural sway.
Third, apart from initial processing of rewards or punishments, impaired integration of reward-punishment information in regions that decide on future behaviors could cause excessive risky behavior; e.g., under risky conditions substance-dependent adults under-recruit specialized conflict-monitoring circuitry in posterior mesofrontal cortex [21]; also see [22], [23].
These results suggest an impaired integration of the TGFβ and RA signals in SLE T cells and implicate the PBX1 gene in this process.
Partial myelination of fibre pathways would also contribute to impaired integration of information in target regions and provide a further source of response variability.
Our study suggest that the short-term benefits of the embedded TA model used in this project, may need to be offset against the longer term costs of delayed or impaired integration.
Moreover, by using different cell systems, we demonstrated that the impaired integration of RA signal at a mutant RARα induces a repression wave that is propagated, in a domino fashion, from RARβ2 to targets downstream of RARβ2.
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However, biomaterial implantation results in unavoidable injury resulting in an inflammatory response, which can impair integration with the host and tissue regeneration.
Hoffman, P., Evans, G. A. & Lambon Ralph, M. A. The anterior temporal lobes are critically involved in acquiring new conceptual knowledge: evidence for impaired feature integration in semantic dementia.
Adams AC, Domouzoglou EM, Chee MJ, Segal-Lieberman G, Pissios P, Maratos-Flier E. Ablation of the hypothalamic neuropeptide melanin concentrating hormone is associated with behavioral abnormalities that reflect impaired olfactory integration.
The functions of one of three marker genes, lys1+, arg1+, and his3+, involved in amino acid synthesis, are impaired by integration of the fragments generated by restriction enzyme digestion of the plasmids.
Retroviral knockdown of miR-132 using a specific 'sponge' containing multiple target sequences impaired the integration of newborn neurons into the excitatory synaptic circuitry of the adult brain.
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