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It's all about strengthening synapses, a process which is chemically impaired in a sleep-deprived brain.
Hippocampal synaptic plasticity and spatial learning are impaired in a rat model of sleep fragmentation.
Decision-making is a complex cognitive process that is impaired in a number of psychiatric disorders.
We found that the transduction efficiencies indeed were impaired in a size-dependent way.
These mice learned a brightness discrimination task well but were impaired in a more difficult pattern discrimination task.
S-phase delay, however, was almost exclusively restricted to sensitive cells and was impaired in a model of treatment-induced resistance.
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In the current study, we have demonstrated that targeted proteasome-mediated degradation is impaired in A-T cells.
These results suggest that targeted proteasome-mediated degradation of polyubiquitylated proteins is impaired in A-T cells.
This is the first study indicating that ubiquitin/26S proteasome pathway is impaired in A-T cells.
These results suggest that targeted proteasome-mediated degradation of the proteasome substrates, in this case the artificial proteasome substrates, is impaired in A-T cells.
This conclusion is based on three major pieces of evidence: First, we demonstrate that proteasome-mediated protein degradation is impaired in A-T cells.
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