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Caution must also be exercised in patients with impaired renal function, impaired hepatic function, severe drug allergies, glucose-6-phosphate dehydrogenase deficiency or blood dyscrasias.
109, 110 Higher risk of hypoglycemia related to SU use is associated with impaired renal function, impaired hepatic function, recent hospitalization, polypharmacy, alcohol use, and caloric restriction in older adults.
Loss of the BPNT1 gene leads to impaired protein synthesis resulting in impaired hepatic function and low serum albumin levels in mice (73).
Impaired hepatic function and histology have been observed in experimental models of diversion of the portal vein blood inflow from the liver and among patients with intestinal failure.
This may lead to AKI and hepatic congestion with cholestasis and impaired hepatic function [14].
This may lead to AKI and hepatic congestion with cholestasis and impaired hepatic function [ 14].
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Additionally this study provides evidence that haemodilutional anaemia to a Hct of 20% does not impair hepatic function and perfusion.
Our study provides evidence that haemodilutional anaemia to a Hct of 20% does not impair hepatic function and perfusion.
Conversely, patients with C-P class B hepatic function tend to have a poor response to treatment, because treatments often further impair hepatic function.
Lumiracoxib is contraindicated in patients with current hepatic disease, previous drug-induced elevations of alanine aminotransferase (ALT /aspartate aminotransferase (AST), ALT/AST >1.5 x upper limit of normal (ULN) before treatment or >3 x ULN during treatment, or taking other drugs that may impair hepatic function (MHRA 2007).
As for the assessment of the preoperative liver function, the current patient showed a relatively high value for ICG-R15 at 26.5%, which ordinarily indicates a moderately impaired hepatic functional reserve.
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