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As a consequence of gut ischemia/hypoxia, IUGR infants are thought to have impaired gut function after birth, which may result in intestinal disturbances, ranging from temporary intolerance to the enteral feeding to full-blown NEC.
IUGR infants are thought to have impaired gut function after birth, which may result in intestinal disturbances, ranging from temporary intolerance to the enteral feeding to full-blown NEC.
In particular, small for gestational age VLBW infants may have impaired gut function, as fetal blood flow to heart, brain and adrenals is compensatory increased, while other organs including the gastro-intestinal tract are relatively hypoperfused in intrauterine growth retardation [ 1].
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NOD2−/− mice have impaired gut barrier function (Barreau et al, 2010).
Impaired gut epithelial barrier function may lead to persistent immune reactions, thus augmenting the gut inflammation [ 6].
We hypothesised that as a result of impaired gut-barrier function endotoxin (lipopolysaccharide), present in the cell-wall of EGNO and in substantial quantities in the gut, is translocated into the bloodstream, and contributes to the pathophysiology of children with severe malaria.
It is suggested that the intense hyperphagia could stem, in part, from impaired gut hormone signaling.
An impaired gut in a child without access to sufficient energy or nutrients will further suffer from impaired healing, with subsequent decline in gut function and nutrient absorption for growth; thus begins a vicious cycle between infection and malnutrition.
Interestingly only gelatine revealed impaired gut microcirculation, whereas HES showed no such effect.
This suggests that intestinal manipulation may impair gut mucosal barrier function and contribute to the systemic inflammatory response seen in AAA surgery.
Do not take laxatives for constipation; they can permanently impair gut motility.
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