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We interpret the impaired response delay compensation after caudal FEF inactivation results (Fig. 10 C, D ) as reflecting primarily impaired generation of motor commands (Fig. 2 E, action).
Antibiotic-treated SPF mice given a sub lethal dose of PR8 virus had impaired generation of virus specific antibody, cluster of differentiation 4+ (CD4+) and CD8+ T cell responses and delayed viral clearance 16.
MC is the first dynamic aphasic case with concurrent deficits in three mechanisms thought crucial for conceptual preparation processes; namely impaired selection, impaired generation of ideas and impaired fluent sequencing of novel thoughts.
Dectin-1 defects and CARD9 defects result in susceptibility to C. albicans because of impaired host recognition of the pathogen and subsequent impaired generation of IL-17-producing T cells.
In these cases, impaired cross-talk between thymocytes and thymic epithelial cells might compromise mechanisms of central tolerance, with failure to delete autoreactive T cells, and with impaired generation of regulatory T (Treg) cells.
A subsequent reduction of the G6PD activity in Fl-intoxicated rats showed impaired generation of NADPH which is required for the reduction of GSSG to GSH (Thangapandiyan & Miltonprabu, 2013).
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Finally, disruption of apical transport of glucose –as shown in our in vitro data– could impair generation of the glucose concentration gradient (Figure 6, D).
Since Vav1-deficiency has been shown to impair generation of effector T cells and cytokine production with deficient IL-4 expression and enhanced Th1 development [41], we examined if Vav1 GEF activity may be essential in this process.
Such complications have been attributed to vascular nitric oxide (NO) depletion via direct scavenging reactions with cell free plasma hemoglobin and impaired NO generation due to enzymatic consumption of arginine by red cell arginase I [1] [3].
Interestingly, two inhibitors of phosphoinositide 3-kinase (PI3K), 3-methyladenine (3MA) and LY294002, severely impaired MIV generation, whereas ROS scavengers, Ebselen and NAC, inhibited the uptake of mitochondria by the MIVs (Figure 6B) under a condition where the Mieap protein was overexpressed.
Consequently, impaired Th17 generation resulted in reduced IL-17 production.
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