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Our study conducted in newly diagnosed stage I and stage II breast cancer patients [ 9] showed impaired functionality of T cells and dendritic cells, which correlated with COX-2 overexpression in the tumors and increased levels of PGE2 in the serum and tumor milieu.
Functionally, LINC00173-knockdown cells showed significantly decreased phagocytic capacity indicating impaired functionality as is expected with perturbed maturation (Fig. 4b and Supplementary Fig. 5d).
We investigated function and localization of G213R rClC-7 to decide whether mislocalization or impaired functionality of G215R ClC-7 is responsible for ADO II.
Furthermore, DC isolated from cancer patients has impaired functionality and possesses an altered phenotype compared to healthy individuals.
As a result, complications such as enduring pain, atrophy and impaired functionality are often encountered.
It is not clear yet how the PARK7 mutations can lead to this impaired functionality.
It may be the case that the functionally impaired group is more dependent on cognitive abilities when overcoming the threat to LS that impaired functionality constitutes.
Rheumatoid arthritis is a costly and debilitating autoimmune disorder that is characterized by joint pain, stiffness, and impaired functionality.
These findings showed that early defects persisted and expanded in the islets of Aldh1b1tm1lacZ null mice, suggesting impaired functionality.
In fact, the muscular proteins are prone to glycation, with resultant impaired functionality, which likely explains the pathophysiology of DM related diaphragm weakness [ 183].
Furthermore, impaired functionality and a reduced number of memory phenotype CD8 T cells were observed after long-term BDE-209 exposure.
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